Handbook of basic pharmacokinetics-- including clinical applications / Wolfgang A. Ritschel, Gregory L. Kearns.
Material type: TextPublication details: Washington, D.C. : American Pharmacists Association, ©2004.Edition: 6th edDescription: xii, 432 pages : illustrations ; 26 cmContent type:- text
- unmediated
- volume
- 1582120544
- 9781582120546
- 615.7 22
- RM301.5 .R57 2004
- 2004 H-729
- QV 39
Item type | Current library | Call number | Status | Date due | Barcode | |
---|---|---|---|---|---|---|
Books | Main library Nursing Buliding | RM301.5 .R57 2004 (Browse shelf(Opens below)) | Not For Loan | N1231 |
Includes bibliographical references and index.
Definitions and glossary -- The LADMER system: liberation, absorption, distribution, metabolism, elimination, and response -- Organs, tissues, cells, and organelles -- Cell membranes -- Drug-receptor interactions -- Absorption/transport mechanisms -- pKa and degree of ionization -- Lipid/water partition coefficient -- Physicochemical factors altering biological performance of drugs -- Biopharmaceutical data of the gastrointestinal tract -- Fluid compartments and circulatory system -- Binding of drugs to biological material -- Drug biotransformation -- Compartment models -- Determination of rate constants -- Volume of distribution and distribution coefficient -- Excretion and clearance of drugs -- Urinary and biliary recycling.
Cumulative urinary excretion -- Area under the blood level-time curve -- Pharmacokinetics of single dose administration -- Pharmacokinetics of multiple dosing -- Compartment model independent analysis -- Pediatric pharmacokinetics -- Drug dosage in elderly patients -- Drug dosage in obese patients -- Drug disposition in pregnancy -- Dosage regimen design -- Drug monitoring and dosage adjustment -- Physiological and pathological factors influencing drug response -- First dosage size in man -- Forensic pharmacokinetics -- Nonlinear pharmacokinetics -- Curve fitting -- Correlation of clinical response with drug disposition -- Bioavailability and bioequivalence -- Body surface areas -- Extracorporeal methods of drug removal -- Pharmacogenetics and pharmacogenomics.
A user-friendly handbook on the principles and techniques involved in the various applications of pharmacokinetics. Provides a concise reference for clinicians who need quick information on the pharmacokinetic characteristics of specific drugs. Thoroughly updated and revised, this book features pharmacokinetic data profiles on more than 600 drugs.
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