Williams hematology editors, Marshall A. Lichtman ... [et al.].

Includes bibliographical references and index.

Approach to the patient -- Examination of the blood -- Examination of the marrow -- The marrow and hematopoietic microenvironment -- The lymphoid tissues -- Hematology of the newborn -- Hematology during pregnancy -- Hematology in the aged -- Genetic principles and molecular biology -- Cytogenetics and gene rearrangement -- Apoptosis -- Cell cycle regulation -- Signal transduction pathways -- The cluster of differentiation (CD) antigens -- Hematopoietic stem cells, progenitor cells, and cytokines -- The inflammatory response -- The innate immune system -- The adaptive immune system and dendritic cells -- Pharmacology and toxicity of antineoplastic drugs -- Treatment of infections in the immunocompromised host -- Principles of antithrombotic therapy -- Principles of hematopoietic stem cell transplantation -- Principles of immune cell therapy -- Principles of vaccine therapy -- Principles of therapeutic apheresis -- Principles of gene transfer for therapy -- Pain management -- Morphology of the erythron -- Composition of the erythrocyte -- Production of erythrocytes -- Destruction of erythrocytes -- Clinical manifestations and classification of erythrocyte disorders -- Aplastic anemia -- Pure red cell aplasia -- Anemia of chronic renal disease -- Anemia of endocrine disorders -- The congenital dyserythropoietic anemias -- Paroxysmal nocturnal hemoglobinuria -- Disorders of folic acid and cobalamin metabolism: the megaloblastic anemias -- Disorders of iron metabolism -- Anemia resulting from other nutritional deficiencies -- Anemia associated with marrow infiltration -- Anemia of chronic disease -- Disorders of the red cell membrane: hereditary spherocytosis, elliptocytosis, and related disorders -- Disorders of red cells resulting from enzyme abnormalities -- Disorders of globin synthesis: the thalassemias -- Disorders of hemoglobin structure: sickle cell anemia and related abnormalities -- Methemoglobinemia and other causes of cyanosis -- Hemolytic anemia resulting from physical injury to red cells -- Hemolytic anemia due to chemical and physical agents -- Hemolytic anemia due to infections with microorganisms -- Hemolytic anemia due to immune injury -- Alloimmune hemolytic disease of the newborn -- Acute blood loss anemia -- Hypersplenism and hyposplenism vPrimary and secondary polycythemia (Erythrocytosis) -- The hematologic aspects of porphyria -- Hereditary and acquired sideroblastic anemias -- Morphology of neutrophils, eosinophils, and basophils -- Composition of neutrophils -- Production, distribution, and fate of neutrophils -- Eosinophils and their disorders vBasophils and mast cells, and their disorders -- Classification and clinical manifestations of neutrophil disorders -- Neutropenia and neutrophilia -- Disorders of neutrophil function -- Morphology of monocytes and macrophages -- Biochemistry and function of monocytes and macrophages -- Production, distribution, and fate of monocytes and macrophages --

Classification and clinical manifestations of disorders of monocytes and macrophages -- Monocytosis and monocytopenia -- Inflammatory and malignant histiocytosis -- Lipid storage diseases -- Morphology of lymphocytes and plasma cells -- Composition and biochemistry of lymphocytes and plasma cells -- Lymphopoiesis -- Functions of B lymphocytes and plasma cells in immunoglobin -- Functions of T lymphocytes: T-cell receptors for antigen -- Functions of natural killer cells -- Classification and clinical manifestations of lymphocytosis and plasma cell disorders -- Lymphocytosis and lymphocytopenia -- Immunodeficiency diseases -- Acquired immunodeficiency syndrome (AIDS) -- Mononucleosis syndromes -- Classification and clinical manifestations of the clonal myeloid disorders -- Myelodysplastic disorders (Clonal cytopenias and oligoblastic leukemia) -- Acute myelogenous leukemia -- Chronic myelogenous leukemia and related disorders -- Idiopathic myelofibrosis (agnogenic myeloid metaplasia) -- Classification of malignant lymphoid disorders -- Acute lymphocytic leukemia -- Chronic lymphocytic leukemia and related diseases -- Hairy cell leukemia -- Large granular lymphocytic leukemia -- Pathology of malignant lymphomas -- The non-Hodgkin lymphomas -- Hodgkin lymphoma -- Plasma cell neoplasms: General considerations -- Essential monoclonal gammopathies -- Plasma cell myeloma -- Amyloidosis -- Macroglobulinemia -- Heavy-chain disease -- Megakaryopoiesis and thrombopoiesis -- Platelet morphology, biochemistry and function -- Molecular biololgy and biochemistry of the coagulation factors and pathways of hemostasis -- Control of coagulation reactions -- Vascular function in hemostasis -- Classification, clinical manifestations and evaluation of disorders of hemostasis -- Thrombocytopenia -- Thrombocytosis and essential thrombocythemia -- Hereditary qualitative platelet disorders -- Acquired qualitative platelet disorders -- The vascular purpuras -- Hemophilia A and hemophilia B -- Inherited deficiencies of coagulation factors II, V, VII, XI and XIIIa -- Hereditary abnormalities of fibrinogen -- von Willebrand disease -- Antibody-mediated coagulation factor deficiencies -- Hemostatic dysfunction related to liver diseases and liver transplantation -- Disseminated intravascular coagulation -- Hereditary thrombophilias -- The antiphospholipid syndrome -- Antibody-mediated thrombotic disorders: thrombotic thrombocytopenia purpura and heparin induced thrombocytopenia -- Venous thrombosis -- Arterial thrombosis -- Fibrinolysis and thrombolysis -- Erythrocyte antigens and antibodies -- Human leukocyte and platelet antigens -- Blood procurement and screening -- Preservation and clinical use of erythrocytes and whole blood -- Preservation and clinical use of platelets.